Cochrane Database of Systematic Reviews
Cochrane review of 252 RCTs showing that antifibrinolytic drugs (tranexamic acid, aminocaproic acid) reduce blood transfusion by about one-third across all surgical settings. Tranexamic acid specifically reduced transfusion probability by 38%.
Tranexamic acid reduced the probability of receiving a blood transfusion by 38% (RR 0.62, 95% CI 0.58 to 0.65) relative to control. Similar reductions were seen with aminocaproic acid.